Association of CDKAL1 gene polymorphisms variations with gestational diabetes mellitus risk in women: A case-control study and meta-analysis

Table 5 The association between genetic variations (SNPs) and blood glucose levels

Genotype	FPG (mmol/L)	1 h-PG (mmol/L)	2 h-PG (mmol/L)
rs7754840 G > C
Years (Age < 30)
GG	4.65 ± 0.06	8.36 ± 0.16	7.24 ± 0.13^a
GC	4.58 ± 0.03	8.50 ± 0.11	7.39 ± 0.09^ab
CC	4.71 ± 0.08	8.66 ± 0.26	7.85 ± 0.24^b
F	1.10	0.64	3.25
P	< 0.05	< 0.05	< 0.05
Age (years) ≥ 30
GG	4.72 ± 0.03	9.46 ± 0.14	8.16 ± 0.14
GC	4.70 ± 0.03	9.52 ± 0.11	8.40 ± 0.11
CC	4.69 ± 0.05	9.62 ± 0.22	8.64 ± 0.18
F	0.23	0.19	2.23
P	> 0.05	> 0.05	> 0.05
rs7756992 A > G
Age (years) < 30
AA	4.63 ± 0.08	8.37 ± 0.19	7.39 ± 0.16
AG	4.63 ± 0.03	8.54 ± 0.12	7.37 ± 0.10
GG	4.62 ± 0.04	8.44 ± 0.18	7.44 ± 0.15
F	0.01	0.37	0.07
P	> 0.05	> 0.05	> 0.05
Age (years) ≥ 30
AA	4.72 ± 0.03	9.40 ± 0.16	8.09 ± 0.15
AG	4.71 ± 0.03	9.63 ± 0.12	8.48 ± 0.12
GG	4.70 ± 0.04	9.44 ± 0.16	8.41 ± 0.16
F	0.04	0.86	2.35
P	> 0.05	> 0.05	> 0.05

^a the impact of rs7754840 genotypes on blood glucose levels was investigated using LSD. Statistically significant differences in blood glucose were observed between individuals with GG and CC genotypes (P < 0.05)

ISSN: 1472-6823