Table 3 The association between genetic variations (SNPs) in the CDKAL1 gene and the likelihood of developing gestational diabetes mellitus in the general subjects

rs7754840 G > C

Codominant Model

GG

219 (45.33)

179(35.80)

1(ref)

1(ref)

GC

228 (43.54)

241(48.20)

1.316 (1.095–1.581)

0.0034

1.251 (0.943–1.660)

0.121

CC

56 (11.13)

80(16.00)

1.748 (1.178–2.529)

0.006

1.715 (1.133–2.595)

0.011

Allele Model

G

665 (66.2)

599 (59.9)

1(ref)

1(ref)

C

339 (33.7)

401 (40.1)

1.313 (1.095–1.575)

0.003

0.767 (0.633–0.928)

0.006

Dominant Model

GG

219(45.33)

179(35.80)

1(ref)

1(ref)

CC + GC

283 (56.37)

321 (64.2)

1.388 (1.076–1.789)

0.11

0.745 (0.570–0.975)

0.032

Recessive Model

GC + GG

446 (88.84)

420 (84.00)

1(ref)

1(ref)

CC

56 (11.13)

80(16.00)

1.517 (1.051–2.189)

0.026

0.659 (0.449–0.968)

0.034

Over dominant Model

CC + GG

275 (54.78)

259 (51.8)

1(ref)

1(ref)

GC

228(43.54)

241(48.20)

0.887 (0.692–1.137)

0.344

0.920 (0.708–1.194)

0.529

rs7756992 A > G

Codominant Model

AA

160 (31.87)

141 (28.20)

1(ref)

1(ref)

AG

234 (46.61)

244 (48.80)

1.105 (0.93–1.313)

0.256

0.973 (0.696–1.360)

0.871

GG

108 (21.51)

115 (23.00)

0.828 (0.585–1.171)

0.285

0.833 (0.578-1.200)

0.325

Allele Model

A

554 (55.10)

526 (52.60)

1(ref)

1(ref)

G

450 (44.80)

474 (47.70)

1.109 (0.9306–1.468)

0.247

0.889 (0.739–1.070)

0.212

Dominant Model

AA

160 (31.87)

141 (28.20)

1(ref)

1(ref)

GG + AG

342 (68.13)

359 (71.80)

1.91 (0.9088–1.561)

0.205

0.848 (0.638–1.128)

0.258

Recessive Model

AG + AA

394 (78.49)

385 (77.00)

1(ref)

1(ref)

GG

108 (21.51)

115 (23.00)

1.09 (0.809–1.468)

0.5718

0.916 (0.669–1.254)

0.583

Overdominant Model

GG + AA

268 (53.39)

256 (51.20)

1(ref)

1(ref)

AG

234 (46.61)

244 (48.80)

0.916 (0.715–1.174)

0.488

0.925 (0.713–1.202)

0.560